Phage Therapy was the treatment of choice before the emergence of antibiotics in the early 1940’s. Because antibiotics are fast acting and effective, Phage Therapy lost favor and quickly died out as the predominate treatment for bacterial infections with a few exceptions as in Tbilisi, Georgia. Alexander Flemming, the creator of penicillin, warned that while antibiotics are effective and fast acting, overuse and abuse would lead to resistant bacteria and antibiotics would become useless. Overuse and misuse of antibiotics in human medicine and in agriculture are at all time highs creating a global catastrophe of emerging bacterial superinfections resistant to most known antibiotics. The Lancet reported in August of 2024, that global deaths due to antibiotic resistance will reach almost 40 million people by the year 2050. Medicine as we currently know it may cease to exist because the risk of surgical infection may become too high in all but the most pressing of cases. Phage Therapy is gaining momentum as a treatment option when antibiotics fail. Researchers across the globe are bringing Phage Therapy to the forefront as a means to stop the global AMR crisis we are facing.